James Ransone — an actor best known for his role in the hit show “The Wire” — has died by suicide, according to the Los Angeles Medical Examiner … TMZ has learned.

TMZ has independently confirmed the star passed away Friday … and the M.E.’s website lists the manner of death as suicide by hanging. We’ve also learned the Los Angeles Police Department responded to a call to a residence, where officers completed a death investigation report and no foul play was suspected.

james-ransone-the-wire-sub-alamy-1

Alamy
Ransone started appearing in small roles in the early 2000s … grabbing parts in the TV shows “Ed” and “Third Watch” … before landing his breakout part in “The Wire.”

James played Ziggy Sobotka — a dock worker and gangster — in all 12 episodes of the show’s second season. His performance received critical acclaim, with some online even calling him one of their favorite characters on the show.

james-ransone-sub-getty-1

Getty
Ransone’s other credits include … “CSI: Crime Scene Investigation,” “Hawaii Five-0,” “Burn Notice,” “Tangerine,” and the Stephen King film, “It: Chapter Two.”

He had a part in “The Black Phone” and “The Black Phone 2” … the latter of which was released earlier this year.